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1

Design and Synthesis of Dipeptidyl Glutaminyl Fluoromethyl Ketones as Potent Severe Acute Respiratory Syndrome Coronovirus (SARS-CoV) Inhibitors

Zhang, Han-Zhong, Zhang, Hong, Kemnitzer, William, Tseng, Ben, Cinatl,, Jindrich, Michaelis, Martin, Doerr, Hans Wilhelm, Cai, Sui Xiong

Journal:

Journal of Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 59 KB

english, 2006

2

Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay

Han-Zhong Zhang, Shailaja Kasibhatla, Yan Wang, John Herich, John Guastella, Ben Tseng, John Drewe, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 384 KB

english, 2004

3

Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: Structure–activity relationships of the 4-anilino group

Nilantha Sirisoma, Shailaja Kasibhatla, Bao Nguyen, Azra Pervin, Yang Wang, Gisela Claassen, Ben Tseng, John Drewe, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 525 KB

english, 2006

4

Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. Part 1: Structure–activity relationships of the 1- and 3-positions

William Kemnitzer, Jared Kuemmerle, Songchun Jiang, Han-Zhong Zhang, Nilantha Sirisoma, Shailaja Kasibhatla, Candace Crogan-Grundy, Ben Tseng, John Drewe, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 194 KB

english, 2008

5

Discovery of substituted 4-anilino-2-arylpyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 2. Structure–activity relationships of the 2-aryl group

Nilantha Sirisoma, Azra Pervin, Bao Nguyen, Candace Crogan-Grundy, Shailaja Kasibhatla, Ben Tseng, John Drewe, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 925 KB

english, 2009

6

Discovery of 4-anilino-N-methylthieno[3,2-d]pyrimidines and 4-anilino-N-methylthieno[2,3-d]pyrimidines as potent apoptosis inducers

William Kemnitzer, Nilantha Sirisoma, Chris May, Ben Tseng, John Drewe, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 440 KB

english, 2009

7

Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2: Structure–activity relationships of the 4-, 5-, 6-, 7- and 8-positions

William Kemnitzer, Jared Kuemmerle, Songchun Jiang, Nilantha Sirisoma, Shailaja Kasibhatla, Candace Crogan-Grundy, Ben Tseng, John Drewe, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 620 KB

english, 2009

8

Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure–activity relationships of the 9-oxo-9H-fluorene ring

William Kemnitzer, Nilantha Sirisoma, Songchun Jiang, Shailaja Kasibhatla, Candace Crogan-Grundy, Ben Tseng, John Drewe, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.10 MB

english, 2010

9

Functionalized Perfluorophenyl Azides: New Reagents for Photoaffinity Labeling

John F.W. Keana, Sui Xiong Cai

Journal:

Journal of Fluorine Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 171 KB

english, 1989

10

Synthesis and SAR of 5-, 6-, 7- and 8-Aza Analogues of 3-Aryl-4-hydroxyquinolin-2(1H)-one as NMDA/Glycine Site Antagonists

Zhang-Lin Zhou, James M Navratil, Sui Xiong Cai, Edward R Whittemore, Stephen A Espitia, Jon E Hawkinson, Minhtam Tran, Richard M Woodward, Eckard Weber, John F.W Keana

Journal:

Bioorganic & Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 289 KB

english, 2001

11

A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo

Craig W. Day, Ralph Baric, Sui Xiong Cai, Matt Frieman, Yohichi Kumaki, John D. Morrey, Donald F. Smee, Dale L. Barnard

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 1.28 MB

english, 2009

12

Synthesis and Structure-Activity Relationships of Substituted 1,4-Dihydroquinoxaline-2,3-diones: Antagonists of N-Methyl-D-aspartate (NMDA) Receptor Glycine Sites and Non-NMDA Glutamate Receptors

Keana, John F. W., Kher, Sunil M., Cai, Sui Xiong, Dinsmore, Christian M., Glenn, Anne G., Guastella, J., Huang, Jin-Cheng, Ilyin, Victor, Lu, Yixin

Journal:

Journal of Medicinal Chemistry

Année:

1995

Langue:

english

Fichier:

PDF, 1.66 MB

english, 1995

13

Synthesis of a 11C-labelled nitrated 1,4-dihydroquinoxaline-2,3-dione, the NMDA glycine receptor antagonist ACEA 1021 (Licostinel)

Jan-Olov Thorell, Sharon Stone-Elander, Tim Duelfer, Sui Xiong Cai, Lawrence Jones, Heidi Pfefferkorn, Grazyna Ciszewska

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

1998

Fichier:

PDF, 581 KB

1998

14

ChemInform Abstract: Design and Synthesis of Rhodamine 110 Derivative and Caspase-3 Substrate for Enzyme and Cell-Based Fluorescent Assay

Sui Xiong Cai, Han-Zhong Zhang, John Guastella, John Drewe, Wu Yang, Eckard Weber

Journal:

Année:

2001

Fichier:

PDF, 28 KB

2001

15

Discovery, Characterization and SAR of Gambogic Acid as a Potent Apoptosis Inducer by a HTS Assay.

Han-Zhong Zhang, Shailaja Kasibhatla, Yan Wang, John Herich, John Guastella, Ben Tseng, John Drewe, Sui Xiong Cai

Journal:

Année:

2004

Fichier:

PDF, 70 KB

2004

16

Dipeptidyl Aspartyl Fluoromethylketones as Potent Caspase-3 Inhibitors: SAR of the P2 Amino Acid.

Yan Wang, Jin-Chen Huang, Zhang-lin Zhou, Wu Yang, John Guastella, John Drewe, Sui Xiong Cai

Journal:

Année:

2004

Fichier:

PDF, 72 KB

2004

17

Dipeptidyl Aspartyl Fluoromethylketones as Potent Caspase Inhibitors: SAR of the N-Protecting Group.

Sui Xiong Cai, Lufeng Guan, Shaojuan Jia, Yan Wang, Wu Yang, Ben Tseng, John Drewe

Journal:

Année:

2005

Fichier:

PDF, 12 KB

2005

18

Discovery of 4-Aryl-4H-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-Based Hight-Throughput Screening Assay. Part 2. Structure—Activity Relationships of the 7- and 5-, 6-, 8-Positions.

Sui Xiong Cai, et al. et al.

Journal:

Année:

2006

Fichier:

PDF, 14 KB

2006

19

ChemInform Abstract: Discovery of 3-Aryl-5-aryl-1,2,4-oxadiazoles as a New Series of Apoptosis Inducers. Part 2. Identification of More Aqueous Soluble Analogues as Potential Anticancer Agents.

William Kemnitzer, Jared Kuemmerle, Han-Zhong Zhang, Shailaja Kasibhatla, Ben Tseng, John Drewe, Sui Xiong Cai

Journal:

Année:

2009

Fichier:

PDF, 19 KB

2009

20

Discovery and SAR of indole-2-carboxylic acid benzylidene-hydrazides as a new series of potent apoptosis inducers using a cell-based HTS assay

Han-Zhong Zhang, John Drewe, Ben Tseng, Shailaja Kasibhatla, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 354 KB

english, 2004

21

Discovery of substituted N′-(2-oxoindolin-3-ylidene)benzohydrazides as new apoptosis inducers using a cell- and caspase-based HTS assay

Nilantha Sirisoma, Azra Pervin, John Drewe, Ben Tseng, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 683 KB

english, 2009

22

Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure–activity relationships of the carboxamide group

William Kemnitzer, Nilantha Sirisoma, Bao Nguyen, Songchun Jiang, Shailaja Kasibhatla, Candace Crogan-Grundy, Ben Tseng, John Drewe, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 1.71 MB

english, 2009

23

Discovery of N-methyl-4-(4-methoxyanilino)quinazolines as potent apoptosis inducers. Structure–activity relationship of the quinazoline ring

Nilantha Sirisoma, Azra Pervin, Hong Zhang, Songchun Jiang, J. Adam Willardsen, Mark B. Anderson, Gary Mather, Christopher M. Pleiman, Shailaja Kasibhatla, Ben Tseng, John Drewe, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 535 KB

english, 2010

24

Discovery and structure–activity relationship of N-phenyl-1H-pyrazolo[3,4-b]quinolin-4-amines as a new series of potent apoptosis inducers

Han-Zhong Zhang, Gisela Claassen, Candace Crogran-Grundy, Ben Tseng, John Drewe, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 256 KB

english, 2008

25

Synthesis of caged 2,3,3a,7a-tetrahydro-3,6-methanobenzofuran-7(6H)-ones: Evaluating the minimum structure for apoptosis induction by gambogic acid

Jared Kuemmerle, Songchun Jiang, Ben Tseng, Shailaja Kasibhatla, John Drewe, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 185 KB

english, 2008

26

Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid

Yan Wang, Jin-Chen Huang, Zhang-lin Zhou, Wu Yang, John Guastella, John Drewe, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 154 KB

english, 2004

27

Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 α-amino acid by a α-hydroxy acid

Yan Wang, Lufeng Guan, Shaojuan Jia, Ben Tseng, John Drewe, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 133 KB

english, 2005

28

Discovery of 5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-7-phenyl-(E)-2,3,6,7-tetrahydro-1,4-thiazepines as a new series of apoptosis inducers using a cell- and caspase-based HTS assay

John Drewe, Shailaja Kasibhatla, Ben Tseng, Emma Shelton, David Sperandio, Robert M. Yee, Joane Litvak, Martin Sendzik, Jeffrey R. Spencer, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 269 KB

english, 2007

29

Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: Peptidomimetic replacement of the P2 amino acid by 2-aminoaryl acids and other non-natural amino acids

Yan Wang, Shaojuan Jia, Ben Tseng, John Drewe, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 143 KB

english, 2007

30

Discovery of (naphthalen-4-yl)(phenyl)methanones and N-methyl-N-phenylnaphthalen-1-amines as new apoptosis inducers using a cell- and caspase-based HTS assay

Songchun Jiang, Candace Crogan-Grundy, John Drewe, Ben Tseng, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 242 KB

english, 2008

31

Discovery of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers. 2. Identification of more aqueous soluble analogs as potential anticancer agents

William Kemnitzer, Jared Kuemmerle, Han-Zhong Zhang, Shailaja Kasibhatla, Ben Tseng, John Drewe, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 1.97 MB

english, 2009

32

4-azido-2-iodo-3,5,6-trifluorophenylcarbonyl derivatives. A new class of functionalized and iodinated perfluorophenyl azide photolabels

Sui Xiong Cai, John F.W. Keana

Journal:

Tetrahedron Letters

Année:

1989

Langue:

english

Fichier:

PDF, 265 KB

english, 1989

33

Design and synthesis of Rhodamine 110 derivative and Caspase-3 substrate for enzyme and cell-based fluorescent assay

Sui Xiong Cai, Han-Zhong Zhang, John Guastella, John Drewe, Wu Yang, Eckard Weber

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 459 KB

english, 2001

34

N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide: A novel antagonist at the 1a/2B NMDA receptor subtype

Amir P. Tamiz, Edward R. Whittemore, Robert M. Schelkun, Po-Wai Yuen, Richard M. Woodward, Sui-Xiong Cai, Eckard Weber, John F.W. Keana

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 175 KB

english, 1998

35

Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists

Zhang-Lin Zhou, Sunil M Kher, Sui Xiong Cai, Edward R Whittemore, Stephen A Espitia, Jon E Hawkinson, Minhtam Tran, Richard M Woodward, Eckard Weber, John F.W Keana

Journal:

Bioorganic & Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 316 KB

english, 2003

36

Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: SAR of the N-protecting group

Sui Xiong Cai, Lufeng Guan, Shaojuan Jia, Yan Wang, Wu Yang, Ben Tseng, John Drewe

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 282 KB

english, 2004

37

MX1013, a dipeptide caspase inhibitor with potent in vivo antiapoptotic activity

Wu Yang, John Guastella, Jin-Cheng Huang, Yan Wang, Li Zhang, Dong Xue, Minhtam Tran, Richard Woodward, Shailaja Kasibhatla, Ben Tseng, John Drewe, Sui Xiong Cai

Journal:

British Journal of Pharmacology

Année:

2003

Langue:

english

Fichier:

PDF, 303 KB

english, 2003

38

Synthesis and Structure−Activity Relationships of 1,2,3,4-Tetrahydroquinoline-2,3,4-trione 3-Oximes: Novel and Highly Potent Antagonists for NMDA Receptor Glycine Site

Cai, Sui Xiong, Zhou, Zhang-Lin, Huang, Jin-Cheng, Whittemore, Edward R., Egbuwoku, Zizi O., Lü, Yixin, Hawkinson, Jon E., Woodward, Richard M., Weber, Eckard, Keana, John F. W.

Journal:

Journal of Medicinal Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 267 KB

english, 1996

39

Discovery and Structure−Activity Relationship of 3-Aryl-5-aryl-1,2,4-oxadiazoles as a New Series of Apoptosis Inducers and Potential Anticancer Agents

Zhang, Han-Zhong, Kasibhatla, Shailaja, Kuemmerle, Jared, Kemnitzer, William, Ollis-Mason, Kristin, Qiu, Ling, Crogan-Grundy, Candace, Tseng, Ben, Drewe, John, Cai, Sui Xiong

Journal:

Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 259 KB

english, 2005

40

Development of Highly Efficient Deep-UV and Electron Beam Mediated Cross-Linkers: Synthesis and Photolysis of Bis(perfluorophenyl) Azides

Glenn, Denis J., Kanskar, Manoj, Wybourne, M. N., Keana, John F. W., Cai, Sui Xiong

Journal:

Chemistry of Materials

Année:

1994

Langue:

english

Fichier:

PDF, 3.07 MB

english, 1994

41

Protection against TNF-Induced Liver Parenchymal Cell Apoptosis during Endotoxemia by a Novel Caspase Inhibitor in Mice

Hartmut Jaeschke, Anwar Farhood, Sui Xiong Cai, Ben Y. Tseng, ary Lynn Bajt

Journal:

Toxicology and Applied Pharmacology

Année:

2000

Langue:

english

Fichier:

PDF, 327 KB

english, 2000

42

Blockade of morphine tolerance by ACEA-1328, a novel NMDA receptor/glycine site antagonist

Kabirullah Lutfy, Ke-Zhong Shen, Ik-Sung Kwon, Sui Xiong Cai, Richard M. Woodward, John F.W. Keana, Eckard Weber

Journal:

European Journal of Pharmacology

Année:

1995

Langue:

english

Fichier:

PDF, 270 KB

english, 1995

43

Pharmacology of ACEA-1416: a potent systemically active NMDA receptor glycine site antagonist

Victor I. Ilyin, Edward R. Whittemore, Minhtam Tran, Ke-Zhong Shen, Sui-Xiong Cai, Sunil M. Kher, John F.W. Keana, Eckard Weber, Richard M. Woodward

Journal:

European Journal of Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 835 KB

english, 1996

44

Selective activation of apoptosis by a novel set of 4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2(1H)-quinolinones through a Myc-dependent pathway

Gisela Claassen, Elena Brin, Candace Crogan-Grundy, Mei Ting Vaillancourt, Han Zhong Zhang, Sui Xiong Cai, John Drewe, Ben Tseng, Shailaja Kasibhatla

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 616 KB

english, 2009

45

103. The Novel Caspase Inhibitor EP1013 Promotes Human Islet Survival and Enhances Marginal Islet Graft Function Following Islet Transplantation

Juliet Emamaullee, Sui Xiong Cai Cai, Ben Tseng, A.M. James Shapiro

Journal:

Journal of Surgical Research

Année:

2008

Langue:

english

Fichier:

PDF, 208 KB

english, 2008

46

Antinociceptive effects of NMDA and non-NMDA receptor antagonists in the tail flick test in mice

Kabirullah Lutfy, Sui Xiong Cai, Richard M Woodward, Eckard Weber

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 881 KB

english, 1997

47

Toward the development of radiolabeled fluorophenyl azide-based photolabeling reagents: synthesis and photolysis of iodinated 4-azidoperfluorobenzoates and 4-azido-3,5,6-trifluorobenzoates

Cai, Sui Xiong, Glenn, Denis J., Keana, John F. W.

Journal:

Journal of Organic Chemistry

Année:

1992

Langue:

english

Fichier:

PDF, 866 KB

english, 1992

48

Discovery of Substituted N -Phenyl Nicotinamides as Potent Inducers of Apoptosis Using a Cell- and Caspase-Based High Throughput Screening Assay

Cai, Sui Xiong, Nguyen, Bao, Jia, Shaojuan, Herich, John, Guastella, John, Reddy, Sanjeeva, Tseng, Ben, Drewe, John, Kasibhatla, Shailaja

Journal:

Journal of Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 183 KB

english, 2003

49

Discovery and structure–activity relationships of (2-(arylthio)benzylideneamino)guanidines as a novel series of potent apoptosis inducers

Han-Zhong Zhang, Candace Crogan-Grundy, Chris May, John Drewe, Ben Tseng, Sui Xiong Cai

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 445 KB

english, 2009

50

V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels

Victor I Ilyin, Dianne D Hodges, Edward R Whittemore, Richard B Carter, Sui Xiong Cai, Richard M Woodward

Journal:

British Journal of Pharmacology

Année:

2005

Langue:

english

Fichier:

PDF, 272 KB

english, 2005